Students learn how molecular shape determines RNA function and explore how RNA is central to life in this media-rich lesson plan from NOVA Labs. The lesson begins with a class discussion about the similarities and differences between RNA and DNA. Students then use the NOVA RNA VirtuaLab game (requires the Flash player plug-in to be installed on computers or a Web browser that supports Flash, such as Chrome) to explore the diverse functions that RNA performs in the cell. In the game, students play the role of a molecular engineer by completing RNA folding puzzles and building RNA molecules out of nucleotides. They conclude the lesson with video quizzes that review the content from the game.